|
ADAMTS9 Protein
|
D000071119 |
[An ADAMTS protease that contains 15 THROMBOSPONDIN (TS) motifs. It cleaves the PROTEOGLYCANS AGGRECAN and VERSICAN and also functions in protein transport from the ENDOPLASMIC RETICULUM to the GOLGI APPARATUS.
] |
|
ADP Ribose Transferases
|
D036002 |
[Enzymes that transfer the ADP-RIBOSE group of NAD or NADP to proteins or other small molecules. Transfer of ADP-ribose to water (i.e., hydrolysis) is catalyzed by the NADASES. The mono(ADP-ribose)transferases transfer a single ADP-ribose. POLY(ADP-RIBOSE) POLYMERASES transfer multiple units of ADP-ribose to protein targets, building POLY ADENOSINE DIPHOSPHATE RIBOSE in linear or branched chains.
, An enzyme that catalyze the transfer of ADP-RIBOSE from NAD+ to an amino acid residue in a specific protein substrate. This reaction is catalyzed by both mono(ADP-ribose) transferases as well as POLY(ADP-RIBOSE) POLYMERASES. When the term NAD+ ADP-Ribosyltransferase refers to EC 2.4.2.30 it is referring to POLY(ADP-RIBOSE) POLYMERASES.
, Enzymes that catalyze the transfer of one ADP-ribose moiety from NAD+ to an amino acid residue in specific protein substrates. This reaction is catalyzed by prokaryotic and eukaryotic enzymes. Mono-ADP-ribosylation is a mechanism of action common to several bacterial toxins.
, An enzyme that catalyzes the transfer of the ADP-ribose moiety from NAD+ or NADP+ to specific protein substrates with arginine, arginine-type compounds, agmatine, or guanidine as acceptors. This mono-ADP-ribosylation reaction is the mechanism of action common to several bacterial toxins affecting profound changes in cellular metabolism, such as activation of adenylate cyclase, regulation of protein synthesis at the level of elongation factor 2, and ion transport across biological membranes.
] |
|
ADP-Ribose 1''-Phosphate Phosphatases
|
D000086922 |
[Enzymes that are highly specific for hydrolysis of the D-ribose 1 phosphate bond of ADP-D-ribose 1''-phosphate to produce ADP-D-ribose and phosphate ion.
] |
|
ADP-Ribosylation
|
D000074744 |
[Post-translational modification of proteins with ADENOSINE DIPHOSPHATE RIBOSE.
] |
|
ADP-Ribosylation Factor 1
|
D020823 |
[ADP-RIBOSYLATION FACTOR 1 is involved in regulating intracellular transport by modulating the interaction of coat proteins with organelle membranes in the early secretory pathway. It is a component of COAT PROTEIN COMPLEX I. This enzyme was formerly listed as EC 3.6.1.47.
] |
|
ADP-Ribosylation Factors
|
D020727 |
[MONOMERIC GTP-BINDING PROTEINS that were initially recognized as allosteric activators of the MONO(ADP-RIBOSE) TRANSFERASE of the CHOLERA TOXIN catalytic subunit. They are involved in vesicle trafficking and activation of PHOSPHOLIPASE D. This enzyme was formerly listed as EC 3.6.1.47
] |
|
ADP-ribosyl Cyclase
|
D036541 |
[A membrane-bound or cytosolic enzyme that catalyzes the synthesis of CYCLIC ADP-RIBOSE (cADPR) from nicotinamide adenine dinucleotide (NAD). This enzyme generally catalyzes the hydrolysis of cADPR to ADP-RIBOSE, as well, and sometimes the synthesis of cyclic ADP-ribose 2' phosphate (2'-P-cADPR) from NADP.
, EC 3.2.2.5
] |
|
ADP-ribosyl Cyclase 1
|
D051997 |
[A bifunctional enzyme that catalyzes the synthesis and HYDROLYSIS of CYCLIC ADP-RIBOSE (cADPR) from NAD+ to ADP-RIBOSE. It is a cell surface molecule which is predominantly expressed on LYMPHOID CELLS and MYELOID CELLS.
] |
|
AGAMOUS Protein, Arabidopsis
|
D026342 |
[A plant homeotic protein involved in the development of stamens and carpels of Arabidopsis thaliana. It is a DNA-binding protein that contains the MADS-box domain. It is one of the four founder proteins that structurally define the superfamily of MADS DOMAIN PROTEINS.
] |
|
AIDS Arteritis, Central Nervous System
|
D020943 |
[Inflammation of ARTERIES in the CENTRAL NERVOUS SYSTEM that occurs in patients with ACQUIRED IMMUNODEFICIENCY SYNDROME or AIDS-RELATED OPPORTUNISTIC INFECTIONS.
] |
|
AIDS Dementia Complex
|
D015526 |
[A neurologic condition associated with the ACQUIRED IMMUNODEFICIENCY SYNDROME and characterized by impaired concentration and memory, slowness of hand movements, ATAXIA, incontinence, apathy, and gait difficulties associated with HIV-1 viral infection of the central nervous system. Pathologic examination of the brain reveals white matter rarefaction, perivascular infiltrates of lymphocytes, foamy macrophages, and multinucleated giant cells. (From Adams et al., Principles of Neurology, 6th ed, pp760-1; N Engl J Med, 1995 Apr 6;332(14):934-40)
] |
|
AIDS Serodiagnosis
|
D015492 |
[Immunologic tests for identification of HIV (HTLV-III/LAV) antibodies. They include assays for HIV SEROPOSITIVITY and HIV SERONEGATIVITY that have been developed for screening persons carrying the viral antibody from patients with overt symptoms of AIDS or AIDS-RELATED COMPLEX.
] |
|
AIDS Vaccines
|
D016915 |
[Vaccines or candidate vaccines containing inactivated HIV or some of its component antigens and designed to prevent or treat AIDS. Some vaccines containing antigens are recombinantly produced.
] |
|
AIDS-Associated Nephropathy
|
D016263 |
[Renal syndrome in human immunodeficiency virus-infected patients characterized by nephrotic syndrome, severe proteinuria, focal and segmental glomerulosclerosis with distinctive tubular and interstitial changes, enlarged kidneys, and peculiar tubuloreticular structures. The syndrome is distinct from heroin-associated nephropathy as well as other forms of kidney disease seen in HIV-infected patients.
] |
|
AIDS-Related Complex
|
D000386 |
[A prodromal phase of infection with the human immunodeficiency virus (HIV). Laboratory criteria separating AIDS-related complex (ARC) from AIDS include elevated or hyperactive B-cell humoral immune responses, compared to depressed or normal antibody reactivity in AIDS; follicular or mixed hyperplasia in ARC lymph nodes, leading to lymphocyte degeneration and depletion more typical of AIDS; evolving succession of histopathological lesions such as localization of Kaposi's sarcoma, signaling the transition to the full-blown AIDS.
] |
|
AIDS-Related Opportunistic Infections
|
D017088 |
[Opportunistic infections found in patients who test positive for human immunodeficiency virus (HIV). The most common include PNEUMOCYSTIS PNEUMONIA, Kaposi's sarcoma, cryptosporidiosis, herpes simplex, toxoplasmosis, cryptococcosis, and infections with Mycobacterium avium complex, Microsporidium, and Cytomegalovirus.
] |
|
AKR murine leukemia virus
|
D000406 |
[A strain of Murine leukemia virus (LEUKEMIA VIRUS, MURINE) isolated from spontaneous leukemia in AKR strain mice.
] |
|
AMP Deaminase
|
D000659 |
[An enzyme that catalyzes the deamination of AMP to IMP. EC 3.5.4.6.
] |
|
AMP-Activated Protein Kinases
|
D055372 |
[Intracellular signaling protein kinases that play a signaling role in the regulation of cellular energy metabolism. Their activity largely depends upon the concentration of cellular AMP which is increased under conditions of low energy or metabolic stress. AMP-activated protein kinases modify enzymes involved in LIPID METABOLISM, which in turn provide substrates needed to convert AMP into ATP.
] |
|
APACHE
|
D018806 |
[An acronym for Acute Physiology and Chronic Health Evaluation, a scoring system using routinely collected data and providing an accurate, objective description for a broad range of intensive care unit admissions, measuring severity of illness in critically ill patients.
] |
