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Reduced factor X activity
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HP_0008321 |
[Reduced activity of coagulation factor X. The extrinsic and intrinsic pathways converge at factor X (fX). The extrinsic pathway activates fX by means of d factor VII with its cofactor, tissue factor. The intrinsic pathway activates fX by means of the tenase complex (Ca2+ and factors VIIIa, IXa and X) on the surface of activated platelets. Factor Xa in turn activates prothrombin (factor II) to thrombin (factor IIa).] |
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Impaired collagen-induced platelet aggregation
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HP_0008320 |
[Abnormal response to collagen or collagen-mimetics as manifested by reduced or lacking aggregation of platelets upon addition collagen or collagen-mimetics.] |
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Elevated urinary dopamine level
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HP_0011979 |
[The concentration of dopamine in the urine, normalized for urine concentration, is above the upper limit of normal.] |
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Cerebral amyloid angiopathy
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HP_0011970 |
[Amyloid deposition in the walls of leptomeningeal and cortical arteries, arterioles, and less often capillaries and veins of the central nervous system.] |
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Paroxysmal lethargy
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HP_0011973 |
[Repeated episodes of sudden-onset and transient lethargy.] |
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Myelofibrosis
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HP_0011974 |
[Replacement of bone marrow by fibrous tissue.] |
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Dermatographic urticaria
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HP_0011971 |
[An exaggerated whealing tendency when the skin is stroked, that is, formation of red, itchy bumps and lines on the skin as a result of pressure on the skin (for instance, stroking the skin with a pen or tongue depressor).] |
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Hypoglycorrhachia
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HP_0011972 |
[Abnormally low glucose concentration in the cerebrospinal fluid.] |
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Abnormal CSF glucose concentration
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HP_0031884 |
[A deviation from normal concentration of glucose content in the cerebrospinal fluid.] |
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normal sensitivity toward
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PATO_0045049 |
[A sensitivity toward an external stimulus which is relatively normal or average] |
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N,N-dimethylglycine
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CHEBI_17724 |
[An N-methylglycine that is glycine carrying two N-methyl substituents.] |
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Unilateral radial aplasia
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HP_0011908 |
[Missing radius bone on one side only associated with congenital failure of development.] |
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Flattened metacarpal heads
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HP_0011909 |
[Abnormally flat shape of the heads of the metacarpal bones.] |
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Reduced beta/alpha synthesis ratio
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HP_0011906 |
[A reduction in the ratio of production of beta globin to that of alpha globin. This is the major abnormality in the various forms of beta thalassemia.] |
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Reduced alpha/beta synthesis ratio
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HP_0011907 |
[A reduction in the ratio of production of alpha globin to that of beta globin. This is the major abnormality in the various forms of alpha thalassemia.] |
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Hypofibrinogenemia
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HP_0011900 |
[Decreased concentration of fibrinogen in the blood.] |
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Dysfibrinogenemia
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HP_0011901 |
[Qualitatively abnormal fibrinogen.] |
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Persistence of hemoglobin F
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HP_0011904 |
[Hemoglobin F (HbF) contains two globin alpha chains and two globin gamma chains. It is the main form of hemoglobin in the fetus during the last seven months of intrauterine development and in the half year of postnatal life. In adults it normally makes up less than one percent of all hemoglobin. This term refers to an increase in HbF above this limit. In beta thalassemia major, it may represent over 90 percent of all hemoglobin, and in beta thalassemia minor it may make up between 0.5 to 4 percent.] |
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Reduced hemoglobin A
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HP_0011905 |
[Hemoglobin A (HbA) contains two globin alpha chains and two globin beta chains. HbA is normally the main adult hemoglobin, representing about 96-98 percent of all hemoglobin. This term represents a decreased in the proportion of HbA below this limit, and can be seen in various forms of thalassemia.] |
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HbH hemoglobin
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HP_0011903 |
[Hemoglobin H (HbH) contains four beta-globin chains. It is normally not present at all in blood, but may make up about 1-40 percent of all hemoglobin in HbH disease, a subform of alpha thalassemia.] |