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Morphine
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DB00295 |
[Morphine is the main alkaloid of opium and it was first obtained from the poppy seeds in 1805.[A176035] It is the most potent analgesic for chronic pain but its use is limited due to the induction of tolerance, severe withdrawal symptoms and high risk of relapse and abuse.[A176050] In its pure form, morphine is ten times more potent than opium and due to this property, it was used extensively in the US Civil War which resulted in approximately 400,000 addicted soldiers. After this event, around the second half of the nineteenth-century, the science made several efforts to find a less addictive alternative which brought the synthesis of [heroin]. However, morphine is still the precursor to other opioids such as [codeine], [fentanyl], [methadone], [hydrocodone], [hydromorphone], [meperidine], and [oxycodone].[L5716] Morphine's first official product was developed by West-Ward Pharmaceuticals Int. and FDA approved in 1984.[L5713]] |
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Dapiprazole
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DB00298 |
[Dapiprazole (U.S. trade name Rev-Eyes) is an alpha blocker. It is found in ophthalmic solutions used to reverse mydriasis after an eye examination.] |
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Bupivacaine
|
DB00297 |
[A widely used local anesthetic agent. [PubChem]] |
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Darexaban
|
DB12289 |
[Darexaban has been used in trials studying the prevention and basic science of Japanese, Caucasian, Thromboembolism, Pharmacodynamics, and Pharmacokinetics, among others.] |
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Verubecestat
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DB12285 |
[Verubecestat is under investigation for the treatment of Alzheimer's Disease, Prodromal Alzheimer's disease, and Amnestic Mild Cognitive Impairment.
Verubecestat is Merck’s investigational oral β-site amyloid precursor protein cleaving enzyme (BACE1 or β secretase) inhibitor. In July 2013, Merck announced positive results for Phase Ib trials of Verubecestat. In the study, administration of Verubecestat at doses of 12, 40 and 60 mg resulted in a dose-dependent and sustained reduction in the levels of Ab40, a measure of BACE1 activity, in CSF from baseline of 57, 79 and 84 percent, respectively.] |
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Simendan
|
DB12286 |
[Simendan is under investigation in clinical trial NCT00527059 (Renal Effects of Levosimendan in Patients Admitted With Acute Decompensated Heart Failure).] |
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Talsaclidine
|
DB12287 |
[Talsaclidine has been used in trials studying the treatment of Alzheimer Disease.] |
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Piromelatine
|
DB12288 |
[Piromelatine has been used in trials studying the treatment of Alzheimer's Disease.] |
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Luspatercept
|
DB12281 |
[Luspatercept is a recombinant fusion protein comprised of a modified extracellular domain of activin receptor type IIB fused to the FC domain of human IgG1.[A187829,L9980] It was first approved for use in the United States in November 2019 under the brand name Reblozyl® for the treatment of anemia in patients with beta thalassemia who require regular blood transfusions.[L9980] Luspatercept is novel in that it ameliorates anemia via action on late-stage erythropoiesis, in contrast to typical erythropoiesis-stimulating agents (ESAs), such as [darbepoetin alfa] and [epoetin alfa], which act only on early-stage erythropoiesis.[A187835] Luspatercept's novel mechanism of action, then, is uniquely suited for the treatment of conditions in which late-stage erythropoiesis is defective, such as beta thalassemia and other myelodysplastic diseases.[A187835,A187838]] |
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Defactinib
|
DB12282 |
[Defactinib has been investigated for the treatment of Malignant Pleural Mesothelioma.] |
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Balapiravir
|
DB12283 |
[Balapiravir has been used in trials studying the treatment of Dengue and Hepatitis C, Chronic.] |
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LY-2608204
|
DB12284 |
[LY2608204 has been used in trials studying the treatment of Diabetes Mellitus, Type 2.] |
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AZD-5423
|
DB12280 |
[AZD5423 has been used in trials studying the basic science and treatment of Asthma, Bioavailability and AUC, and Chronic Obstructive Pulmonary Disease (COPD).] |
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N7-(5'-Phospho-alpha-ribosyl)-2-hydroxypurine
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DB02905 |
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(2s,4s)-Alpha-Campholinic Acid
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DB02906 |
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1,3-bis-([[3-(4-{3-[3-nitro-5-(galactopyranosyloxy)-benzoylamino]-propyl}-piperazin-1-yl)-propylamino-3,4-dioxo-cyclobutenyl]-amino-ethyl]-amino-carbonyloxy)-2-amino-propane
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DB02903 |
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Beta-3-Serine
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DB02904 |
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Stanolone
|
DB02901 |
[A potent androgenic metabolite of testosterone. Dihydrotestosterone (DHT) is generated by a 5-alpha reduction of testosterone. Unlike testosterone, DHT cannot be aromatized to estradiol therefore DHT is considered a pure androgenic steroid.] |
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3'-Phosphate-Adenosine-5'-Phosphate Sulfate
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DB02902 |
[3'-Phosphoadenosine-5'-phosphosulfate. Key intermediate in the formation by living cells of sulfate esters of phenols, alcohols, steroids, sulfated polysaccharides, and simple esters, such as choline sulfate. It is formed from sulfate ion and ATP in a two-step process. This compound also is an important step in the process of sulfur fixation in plants and microorganisms. [PubChem]] |
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alpha-D-mannose 6-phosphate
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DB02900 |
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