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Polydatin
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DB11263 |
[Polydatin, or Piceid, is a natural precursor and glycoside form of resveratrol with a monocrystalline structure. While it is isolated from the bark of *Picea sitchensis* or *Polygonum cuspidatum*, polydatin may be detected in grape, peanut, hop cones, red wines, hop pellets, cocoa-containing products, chocolate products and many daily diets [A27226]. Polydatin possesses anti-inflammatory, immunoregulatory, anti-oxidative and anti-tumor activities. It is shown to mediate a cytotoxic action on colorectal cancer cells by inducing cell arrest and apoptosis [A27229].] |
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Bisoctrizole
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DB11262 |
[Bisoctrizole, or methylene bis-benzotriazolyl tetramethylbutylphenol, is a broad-spectrum organic UV filter that is marketed as Tinosorb M [A19212]. It is a benzotriazole-based organic compound that absorbs, reflects, and scatters both UV-A and UV-B rays. Bisoctrizole is not approved by the FDA, but is approved in the EU and other parts of the world as a UV-filter in sunscreens, day care products and skin lightening products at a maximum concentration of 10% [F90].] |
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Diethylamino hydroxybenzoyl hexyl benzoate
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DB11269 |
[Diethylamino hydroxybenzoyl hexyl benzoate is a UV filter with high absorption in the UV-A range. Minimizing the overexposure of human skin to ultraviolet radiation that may lead to acute and chronic photodamage, diethylamino hydroxybenzoyl hexyl benzoate is an oil-soluble UV filter that may be incorporated in the oil phase of emulsions [F107]. Diethylamino hydroxybenzoyl hexyl benzoate was approved in Europe in 2005, and is also marketed in the U.S., South America, Mexico, Japan and Taiwan. It has a chemical structure similar to the classical benxophoenone drug class, and displays good photostability [A33171]. It is used in concentrations up to 10% in sunscreen products, either alone or in combination with other UV absorbers [F107].] |
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Apaziquone
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DB12593 |
[Apaziquone has been investigated for the treatment of Bladder Cancer and Bladder Neoplasms.] |
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Protocatechualdehyde
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DB11268 |
[Also known as protocatechuic aldehyde, protocatechualdehyde is a naturally-occuring phenolic aldehyde that is found in barley, green cavendish bananas, grapevine leaves and root of the herb S. miltiorrhiza [A27224]. Protocatechualdehyde possesses antiproliferative and pro-apoptotic properties against human breast cancer cells and colorectal cancer cells by reducing the expression of pro-oncogenes β-catenin and cyclin D1.] |
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AZD-9056
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DB12594 |
[AZD9056 has been used in trials studying the basic science and treatment of Rheumatoid Arthritis.] |
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Triethoxycaprylylsilane
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DB11267 |
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Na-1
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DB12595 |
[Na 1 is under investigation in clinical trial NCT00728182 (Evaluating Neuroprotection in Aneurysm Coiling Therapy).] |
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Combretastatin
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DB12596 |
[Combretastatin has been investigated for the treatment of Anaplastic Thyroid Cancer.] |
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Sea salt
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DB11266 |
[Sea salt is the salt obtained from the evaporation of seawater or water from saltwater lakes. Sea salt production is subject to little processing which leaves certain trace minerals and elements behind. In comparison, table salt is mined from underground sedimentary deposits and is more heavily processed to eliminate minerals. Unlike sea salt, table salt usually contains an additive to prevent clumping and involves addition of iodine. Sea salt is a food ingredient and is often colored by adding charcoal or red clay to sometimes be referred to as “Hawaiian Sea Salt.”] |
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Indiplon
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DB12590 |
[Indiplon has been used in trials studying the treatment of Insomnia and Depression.] |
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BMS-911543
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DB12591 |
[BMS-911543 has been used in trials studying the treatment of Cancer.] |
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EC-18
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DB12592 |
[EC-18 has been used in trials studying the supportive care and treatment of Chemotherapy-induced Neutropenia.] |
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Atractylodes japonica root
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DB11261 |
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Diacetyl benzoyl lathyrol
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DB11260 |
[Diacetyl benzoyl lathyrol is an active ingredient in whitening creams. It is also reported to be a skin conditioning agent.] |
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Pine needle oil (pinus mugo)
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DB11276 |
[Pine needle oil is obtained from the needles of *Pinus mugo* tree via steam distillation. Major components of pine needle oil (pinus mugo) include α-Pinene, β-pinene, δ-3-carene, limonene, β-phellandrene, (E)-caryophyllene, and germacrene D. It is present in aromatherapeutic agents as a massage oil or fragrance and may also be used as a disinfectant, lubricant, sanitizer, antimicrobial, insecticide and organic herbicide.] |
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Epicriptine
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DB11275 |
[Epicriptine is also known as beta-dihydroergocryptine presents a molecular formula of 9,10 alpha-dihydro-13'-epi-b-ergocryptine. Together with the alpha-dihydroergocryptine, it represents one-third of the ergoloid mesylate mixture. Epicriptine differs from the alpha form on the position of one methyl group.[T195] To know more about the mixture please visit [DB01049]] |
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Dihydro-alpha-ergocryptine
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DB11274 |
[Alpha-dihydroergocryptine is usually referred to the mixture of the alpha and beta dihydroergocryptine. These two compounds are differentiated in the position of a methyl group. This structural difference is due to a proteinogenic amino acid replacement from leucine to isoleucine.[T195] Both compounds are hydrogenated ergot derivatives. Alpha-dihydroergocryptine approved drug product is as a part of an ergoloid mixture. To know more about this mixture, please visit [DB01049]] |
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Dihydroergocornine
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DB11273 |
[Dihydroergocornine is one of the dihydrogenated ergot compounds that present very large hypotensive effects.[A32962] It is an artificial derivative of the crude extract of ergot and later purified, ergocornine.[A32964] The formation of dihydroergocornine implies the hydrogenation of the double bonds in the lysergic acid.[A32965] Dihydroergocornine presents a formula of 9,10 alpha-dihydro-12'-hydroxy-2',5'alpha-bis(1-methylethyl)-ergotaman-3',6',18-trione.[T190] It is found as one of the components in the ergoloid mesylate mixture. To know more about this mixture please refer to [DB01049]] |
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Brilliant green cation
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DB11279 |
[Brilliant green, or ethanaminium, is a derivative of triarylmethane dye that has been used as a dye to color silk and wool. Due to its inhibitory actions against Gram positive microorganisms, brilliant green can be found in antiseptic products such as solutions and swabs used to prevent infection.] |