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Halazepam
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DB00801 |
[Halazepam is a _benzodiazepine_ derivative drug exerting anxiolytic, anticonvulsant, sedative, a muscle relaxing effects.[A1212, A178114] It has been shown to be less toxic than chlordiazepoxide or diazepam.[A1212] This drug is no longer marketed in the United States, and was withdrawn by _Schering_, its manufacturer, in 2009.[L6226, L6229]] |
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Fenoldopam
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DB00800 |
[A dopamine D1 receptor agonist that is used as an antihypertensive agent. It lowers blood pressure through arteriolar vasodilation.] |
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Cepeginterferon alfa-2B
|
DB12814 |
[Cepeginterferon alfa-2B is under investigation in clinical trial NCT01889433 (An Open-label Comparative Efficacy and Safety Study of Algeron (Cepeginterferon Alfa-2b) in Treatment-naive Patients With Chronic Hepatitis C).] |
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Crotedumab
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DB12815 |
[Crotedumab has been used in trials studying the treatment of Diabetes Mellitus, Type 2.] |
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Terpinen-4-ol
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DB12816 |
[Terpinen-4-ol is under investigation in clinical trial NCT01647217 (Demodex Blepharitis Treatment Study).] |
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Zoliflodacin
|
DB12817 |
[Zoliflodacin has been used in trials studying the basic science and treatment of Gonorrhoea.] |
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AN-2718
|
DB12810 |
[An2718 has been used in trials studying Tinea Pedis.] |
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Palomid 529
|
DB12812 |
[Palomid 529 has been used in trials studying the treatment of Age-Related Macular Degeneration.] |
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Radium Ra-223
|
DB12813 |
[Radium 223 is under investigation in clinical trial NCT02463799 (Ph 2 Study of Sipuleucel-T W/ or W/O Radium-223 in Men With Asymptomatic or Minimally Symptomatic Bone-MCRPC).] |
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Diazepam
|
DB00829 |
[A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of gamma-aminobutyric acid activity. It is used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome. (From Martindale, The Extra Pharmacopoeia, 30th ed, p589)
Given diazepam's storied history as a commonly used and effective medication for a variety of indications, contemporary advancements in the formulation and administration of the agent include the development and US FDA approval of an auto-injectable formulation for the rapid treatment of uncontrolled seizures in 2015-2016 [L5200]. Combining diazepam, a proven effective therapy for acute repetitive seizures, with an auto-injector designed for subcutaneous administration that is quickly and easily administered offers the potential for complete, consistent drug absorption and rapid onset of effect [L5200]. This current development is subsequently an important addition to the rescue therapy tool chest for patients with epilepsy [L5200].] |
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Fosfomycin
|
DB00828 |
[An antibiotic produced by Streptomyces fradiae.] |
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Loperamide
|
DB00836 |
[One of the long-acting synthetic antidiarrheals; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.] |
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Brompheniramine
|
DB00835 |
[Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria.] |
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Clocortolone
|
DB00838 |
[Clocortolone is a medium potency corticosteroid that is often used as a topical cream for the relief of inflammatory oand pruritic (itching) arising from steroid-responsive dermatoses of the scalp.] |
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Progabide
|
DB00837 |
[Progabide is an analog and prodrug of gamma-aminobutyric acid. It is commonly used in the treatment of epilepsy. It has agonistic activity for both the GABAA and GABAB receptors. In clinical trials, progabide has been investigated for Parkinson's disease, schizophrenia, clinical depression and anxiety disorder; its therapeutic effectiveness in these conditions is not fully elucidated.] |
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Phensuximide
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DB00832 |
[Phensuximide is a member of the succinimide class with anticonvulsant properties. It suppresses the paroxysmal three cycle per second spike and wave EEG pattern associated with lapses of consciousness in petit mal seizures. The frequency of attacks is reduced by depression of nerve transmission in the motor cortex.] |
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Trifluoperazine
|
DB00831 |
[A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic.] |
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Mifepristone
|
DB00834 |
[Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary cushing syndrome. The two marketed forms of mifepristone are Mifeprex® (mifepristone 200mg) and Korlym™ (mifepristone 300mg). Currently under investigation for use in psychotic depression (phase 3 trials).] |
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Cefaclor
|
DB00833 |
[Semisynthetic, broad-spectrum antibiotic derivative of cephalexin.] |
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Phenmetrazine
|
DB00830 |
[A sympathomimetic drug used primarily as an appetite depressant. Its actions and mechanisms are similar to dextroamphetamine.] |
