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β-Hydroxythiofentanyl
|
DB09170 |
[β-Hydroxythiofentanyl is an analgesic of the _opioid_ class. This drug is an analog of fentanyl, a potent opioid.] |
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Brifentanil
|
DB09172 |
[Brifentanil (also known as A-3331) is an analog of fentanyl, a potent opioid. This drug is classified as an opioid analgesic and was developed in the early 1990s. The effects of brifentanil are very similar to those of alfentanil, with strong but short lasting analgesia and sedation, and particularly notable itching and respiratory depression.] |
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Sarafloxacin
|
DB11491 |
[Sarafloxacin is a quinolone antibiotic drug, which was discontinued by its manufacturer, Abbott Laboratories, before receiving approval for use in the US or Canada.] |
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β-Methylfentanyl
|
DB09171 |
[β-Methylfentanyl is an analgesic of the _opioid_ class. It is an analog of the potent opioid, fentanyl.] |
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Nalorphine
|
DB11490 |
[Nalorphine is a mixed opioid agonist–antagonist. It acts at two opioid receptors—at the mu receptor it has antagonistic effects, and at the kappa receptors it exerts high-efficacy agonistic characteristics. It is used to reverse opioid overdose and (starting in the 1950s) in a challenge test to determine opioid dependence.] |
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Lofentanil
|
DB09174 |
[Lofentanil is an analog of fentanyl and is one of the most potent opioids available today. It displays most similarity to carfentanil (4-carbomethoxyfentanyl) and is considered to be slightly more potent than this drug.] |
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Butyrfentanyl
|
DB09173 |
[Butyrfentanyl or butyrylfentanyl (not to be confused with 3-methylfentanyl) is a potent short-acting synthetic opioid analgesic drug.[A182054] It is an analog of [fentanyl] with roughly 1/30 the potency.[L7811] Butyrfentanyl was first synthesized in 1961 by Janssen Pharmaceuticals as a new opioid analgesic.[L7811]
Butyrfentanyl has no current legitimate clinical applications, but anecdotal reports indicate it may occasionally be surfacing on the grey-market as a recreational drug.[L7811] This compound is a schedule I controlled substance in the USA because it is a positional isomer of 3-Methylfentanyl.[L7814]
The DEA in the United States has confirmed at least 40 fatalities involving butyrfentanyl before May 2016.[L7811]] |
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Mirfentanil
|
DB09175 |
[Mirfentanil is a derivative of fentanyl that presents high selectivity for the mu opioid receptor. At lower doses, it antagonizes the analgesic effects of alfentanil and substitutes for naloxone in morphine-treated monkeys; however, it also reverses naloxone-precipitated withdrawal in pigeons trained to discriminate morphine from naloxone. At high doses, it exhibits analgesic activity which is not fully reversed by opioid antagonists, suggesting that the drug has both opioid and non-opioid mechanisms of action.] |
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Phenaridine
|
DB09178 |
[Phenaridine (2,5-Dimethylfentanyl) is a synthetic fentanyl derivative opioid. It was developed in 1972, and is used for surgical anasthesia in Russia. Phenaridine has similar effects to fentanyl. In rat studies, it was less potent than fentanyl. Side effects include itching, nausea and serious to life threatening respiratory depression. Fentanyl analogs have killed hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early 2000s, and novel derivatives continue to appear.] |
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p-Fluorofentanyl
|
DB09177 |
[p-Fluorofentanyl is an opioid analgesic being an analogue of fentanyl developed by Janssen Pharmaceutica in the 1960s. p-Fluorofentanyl was sold briefly on the US black market in the early 1980s, before the introduction of the Federal Analog Act which for the first time attempted to control entire families of drugs based on their structural similarity rather than scheduling each drug individually as they appeared. p-Fluorofentanyl is made with the same synthetic route as fentanyl, but by substituting para-fluoroaniline for aniline in the synthesis.] |
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R-30490
|
DB09179 |
[R-30490 is an opioid related to carfentanil used as an animal tranquilizer. It was first synthesized by Janssen Pharmaceutica as part of a structure-activity relationship study of fentanly and its derivatives. R-30490 was found to be the most selective agonist for the mu opioid receptor out of all the fentanyl analogues tested, but it has never been introduced for medical use in humans, although the closely related drug sufentanil is widely used for analgesia and anesthesia during major surgery.] |
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Tiamulin
|
DB11468 |
[Tiamulin is a pleuromutilin antibiotic drug that is used in veterinary medicine particularly for pigs and poultry.] |
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Laniquidar
|
DB12799 |
[Laniquidar has been used in trials studying the treatment of Breast Cancer.] |
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CMX-2043
|
DB12795 |
[CMX-2043 has been used in trials studying the treatment and prevention of Non STEMI, Unstable Angina, Stable Coronary Artery Disease, and Percutaneous Coronary Intervention.] |
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Sulfanitran
|
DB11463 |
|
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Sulfaethoxypyridazine
|
DB11462 |
|
|
MRX-I
|
DB12796 |
[MRX-I has been used in trials studying the treatment of Bacterial Infections.] |
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Sulfachlorpyridazine
|
DB11461 |
[A sulfonamide antimicrobial used for urinary tract infections and in veterinary medicine.] |
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Ecromeximab
|
DB12797 |
[Ecromeximab has been used in trials studying the treatment of Cutaneous Melanoma and Metastatic Melanoma.] |
|
Relenopride
|
DB12798 |
[Relenopride has been used in trials studying the treatment of Chronic Idiopathic Constipation.] |
