Signaling proteins which function as master molecular switches by activating Rho GTPases through conversion of guanine nucleotides. Rho GTPases in turn control many aspects of cell behavior through the regulation of multiple downstream signal transduction pathways.

Synonyms: Protein, Cool-1 Cool-1 Protein Protein, betaPIX betaPIX Protein Cool 1 Protein PIX Protein, beta PAK-Interacting Exchange Factor beta Protein, beta PIX Rho Guanine Nucleotide Exchange Factor p115 PAK Interacting Exchange Factor beta Rho Guanine Nucleotide Exchange Factors p115RhoGEF 0 beta PIX Protein RhoGEF ARHGEF1 RhoGEF, p115 p115 RhoGEF Rho Guanine Nucleotide Exchange Factor (GEF) 1 Rho Guanine Nucleotide Exchange Factor 6 Rho Guanine Nucleotide Exchange Factor 7