A phosphoinositide phospholipase C subtype that is primarily regulated by its association with HETEROTRIMERIC G-PROTEINS. It is structurally related to PHOSPHOLIPASE C DELTA with the addition of C-terminal extension of 400 residues.

Synonyms: PLC beta2 PLC beta1 PLC beta4 PLC beta3 Phospholipase C-beta Phospholipase C-beta4 Phospholipase C-beta3 Phospholipase C beta4 Phospholipase C-beta2 Phospholipase C beta2 Phospholipase C-beta1 Phospholipase C beta3 Phospholipase C beta1 Phospholipase C beta PLC beta EC 3.1.4.11