A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC GMP. It is found predominantly in vascular tissue and plays an important role in regulating VASCULAR SMOOTH MUSCLE contraction.

Synonyms: Phosphodiesterase 5 Phosphodiesterase Type 5 Phosphodiesterase V Cyclic Nucleotide Phosphodiesterases, Type 5 cGMP-Specific Phosphodiesterase 5A cGMP-Binding, cGMP-Specific 3',5'-cyclic Nucleotide Phosphodiesterase Phosphodiesterase 5A Type 5, Phosphodiesterase Phosphodiesterase 5A, cGMP-Specific Type V, Phosphodiesterase PDE5 Phosphodiesterases EC 3.1.4.35 Phosphodiesterases, PDE5 Phosphodiesterase 5A, cGMP Specific Phosphodiesterase-5 Phosphodiesterase Type V