A cyclic nucleotide phosphodiesterase subfamily that is found predominantly in inflammatory cells and may play a role in the regulation of CELL-MEDIATED IMMUNITY. The enzyme family includes over twenty different variants that occur due to multiple ALTERNATIVE SPLICING of the mRNA of at least four different genes.

Synonyms: Phosphodiesterase 4 PDE4D3 Phosphodiesterase Cyclic Nucleotide Phosphodiesterase PDE4 Family Cyclic Nucleotide Phosphodiesterases, Type 4A5 Cyclic Nucleotide Phosphodiesterases, Type 4 EC 3.1.4.- Phosphodiesterase IV Cyclic Nucleotide Phosphodiesterases, Type 4D Cyclic Nucleotide Phosphodiesterases, Type 4C PDE4 Phosphodiesterases Cyclic Nucleotide Phosphodiesterases, Type 4B Cyclic Nucleotide Phosphodiesterases, Type 4A cAMP-Specific Phosphodiesterase 4A5 Phosphodiesterases, PDE4 Phosphodiesterase 4A5, cAMP-Specific Type 4 Cyclic Nucleotide Phosphodiesterase Phosphodiesterase, PDE4D3 Phosphodiesterase 4A Phosphodiesterase 4C Phosphodiesterase 4B Phosphodiesterase-4 Phosphodiesterase 4D EC 3.1.4.17 cAMP Specific Phosphodiesterase 4A5 Cyclic Nucleotide Phosphodiesterases, Type 4D3