A CALCIUM and CALMODULIN-dependent cyclic nucleotide phosphodiesterase subfamily. The three members of this family are referred to as type 1A, type 1B, and type 1C and are each product of a distinct gene. In addition, multiple enzyme variants of each subtype can be produced due to multiple alternative mRNA splicing. Although the type 1 enzymes are classified as 3',5'-cyclic-AMP phosphodiesterases (EC 3.1.4.17), some members of this class have additional specificity for CYCLIC GMP.

Synonyms: Cyclic Nucleotide Phosphodiesterases, Type 1 Calcium-Calmodulin-Dependent Phosphodiesterase Phosphodiesterase 1C, Calmodulin-Dependent Cyclic Nucleotide Phosphodiesterase PDE1 Family PDE1 Phosphodiesterases Calcium Calmodulin Stimulated Cyclic AMP Phosphodiesterase Phosphodiesterases, PDE1 Calmodulin-Dependent cGMP Phosphodiesterase Calcium-Calmodulin-Stimulated Cyclic AMP Phosphodiesterase Calmodulin Dependent cGMP Phosphodiesterase Phosphodiesterase 1B, Calmodulin-Dependent Phosphodiesterase 1A, Calmodulin Dependent Ca-CaM-Phosphodiesterase Calmodulin-Dependent Phosphodiesterase Calmodulin Phosphodiesterase Phosphodiesterase 1C, Calmodulin Dependent cGMP Phosphodiesterase, Calmodulin-Dependent Cyclic Nucleotide Phosphodiesterases, Type 1C Cyclic Nucleotide Phosphodiesterases, Type 1B Cyclic Nucleotide Phosphodiesterases, Type I Cyclic Nucleotide Phosphodiesterases, Type 1A Calmodulin Dependent Phosphodiesterase Phosphodiesterase 1B, Calmodulin Dependent Calmodulin-Dependent Phosphodiesterase 1B Ca CaM Phosphodiesterase Ca(2+)-CaM-Stimulated PDE Calmodulin-Dependent Phosphodiesterase 1A Phosphodiesterase 1A, Calmodulin-Dependent Calmodulin-Dependent Phosphodiesterase 1C Phosphodiesterase, Calcium-Calmodulin-Dependent EC 3.1.4.17 Ca++ Calmodulin Dependent Cyclic AMP Phosphodiesterase Calcium Calmodulin Dependent Phosphodiesterase Phosphodiesterase, Calmodulin-Dependent cGMP