A subtype of non-receptor protein tyrosine phosphatases that contain two SRC HOMOLOGY DOMAINS. Mutations in the gene for protein tyrosine phosphatase, non-receptor type 11 are associated with NOONAN SYNDROME.

Synonyms: Shp 2 Tyrosine Phosphatase Protein Tyrosine Phosphatase, Non-Receptor Type 11 Phosphatase, SHP2 Protein Tyrosine Phosphatase PTP3 SHPTP2 Phosphotyrosine Phosphatase Syp Tyrosine Phosphatase, Shp-2 Protein Tyrosine Phosphatase, Non Receptor Type 11 Shp-2 Tyrosine Phosphatase Protein Tyrosine Phosphatase 2C Protein-Tyrosine-Phosphatase 2C SHP2 Phosphatase SHP-2 Protein-Tyrosine Phosphatase EC 3.1.3.48