Cell surface receptors for obesity factor (LEPTIN), a hormone secreted by the WHITE ADIPOCYTES. Upon leptin-receptor interaction, the signal is mediated through the JAK2/STAT3 pathway to regulate food intake, energy balance and fat storage.

Isoform A is expressed in fetal liver, hematopoietic tissues, and choroid plexus.

Isoform B is highly expressed in hypothalamus.

Synonyms: Receptor, OBRb Receptor, OB Receptors, Leptin Receptor, OBRa Leptin Receptors Leptin Receptor, Large Isoform CD295 Antigens Leptin Binding Protein Receptor, Leptin OBRb Receptor Leptin-Binding Protein LEPR Protein OB Receptor 0 OBRa Receptor Antigens, CD295 Leptin Receptor Leptin Receptor, Small Isoform