Formate-Tetrahydrofolate Ligase

Formate-Tetrahydrofolate Ligase

http://id.nlm.nih.gov/mesh/D005574

A carbon-nitrogen ligase that catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate in the presence of ATP. In higher eukaryotes the enzyme also contains METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NADP+) and METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE activity.

Synonyms: Formate:tetrahydrofolate ligase (ADP-forming) Formyltetrahydrofolate Synthetase Formate Tetrahydrofolate Ligase Tetrahydrofolate Formylase EC 6.3.4.3 Formylase, Tetrahydrofolate Synthetase, Formyltetrahydrofolate Ligase, Formate-Tetrahydrofolate Formate-Tetrahydrofolate Ligase

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Term information

comment

98(75)

98; see FORMYLTETRAHYDROFOLATE SYNTHETASE 1991-97; see LIGASES 1975-90

identifier

D005574

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