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Apoptosomes
|
D053478 |
[Multimeric protein complexes formed in the CYTOSOL that play a role in the activation of APOPTOSIS. They can occur when MITOCHONDRIA become damaged due to cell stress and release CYTOCHROME C. Cytosolic cytochrome C associates with APOPTOTIC PROTEASE-ACTIVATING FACTOR 1 to form the apoptosomal protein complex. The apoptosome signals apoptosis by binding to and activating specific INITIATOR CASPASES such as CASPASE 9.
] |
|
Apoptotic Protease-Activating Factor 1
|
D053477 |
[A CARD signaling adaptor protein characterized by an N-terminal CARD DOMAIN and C-terminal WD40 REPEATS. It plays a role in the mitochondria-stimulated apoptosis (APOPTOSIS, INTRINSIC PATHWAY) and binds to CYTOCHROME C in the CYTOSOL to form an APOPTOSOMAL PROTEIN COMPLEX which activates INITIATOR CASPASES such as CASPASE 9.
] |
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Aporphines
|
D001060 |
[Dibenzoquinolines derived in plants from (S)-reticuline (BENZYLISOQUINOLINES).
] |
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Appalachian Region
|
D001061 |
[A geographical area of the United States with no definite boundaries but comprising northeastern Alabama, northwestern Georgia, northwestern South Carolina, western North Carolina, eastern Kentucky, eastern Tennessee, western Virginia, West Virginia, western Maryland, southwestern Pennsylvania, southern Ohio, and southern New York.
] |
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Appendectomy
|
D001062 |
[Surgical removal of the vermiform appendix. (Dorland, 28th ed)
] |
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Appendiceal Neoplasms
|
D001063 |
[Tumors or cancer of the APPENDIX.
] |
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Appendicitis
|
D001064 |
[Acute inflammation of the APPENDIX. Acute appendicitis is classified as simple, gangrenous, or perforated.
] |
|
Appendix
|
D001065 |
[A worm-like blind tube extension from the CECUM.
] |
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Appetite
|
D001066 |
[Natural recurring desire for food. Alterations may be induced by APPETITE DEPRESSANTS or APPETITE STIMULANTS.
] |
|
Appetite Depressants
|
D001067 |
[Agents that are used to suppress appetite.
] |
|
Appetite Regulation
|
D001069 |
[Physiologic mechanisms which regulate or control the appetite and food intake.
] |
|
Appetite Stimulants
|
D019167 |
[Agents that are used to stimulate appetite. These drugs are frequently used to treat anorexia associated with cancer and AIDS.
] |
|
Appetitive Behavior
|
D001070 |
[Animal searching behavior. The variable introductory phase of an instinctive behavior pattern or sequence, e.g., looking for food, or sequential courtship patterns prior to mating.
] |
|
Applied Behavior Analysis
|
D000072357 |
[Behavioral science applied with the aim of improving socially important issues such as behavior problems and learning. For individuals diagnosed with intellectual and developmental disabilities including AUTISM, techniques can be categorized as comprehensive or focused.
] |
|
Appointments and Schedules
|
D001071 |
[The different methods of scheduling patient visits, appointment systems, individual or group appointments, waiting times, waiting lists for hospitals, walk-in clinics, etc.
] |
|
Apraxia, Ideomotor
|
D020240 |
[A form of apraxia characterized by an acquired inability to carry out a complex motor activity despite the ability to mentally formulate the action. This condition has been attributed to a disruption of connections between the dominant parietal cortex and supplementary and premotor cortical regions in both hemispheres. (From Adams et al., Principles of Neurology, 6th ed, p57)
] |
|
Apraxias
|
D001072 |
[A group of cognitive disorders characterized by the inability to perform previously learned skills that cannot be attributed to deficits of motor or sensory function. The two major subtypes of this condition are ideomotor (see APRAXIA, IDEOMOTOR) and ideational apraxia, which refers to loss of the ability to mentally formulate the processes involved with performing an action. For example, dressing apraxia may result from an inability to mentally formulate the act of placing clothes on the body. Apraxias are generally associated with lesions of the dominant PARIETAL LOBE and supramarginal gyrus. (From Adams et al., Principles of Neurology, 6th ed, pp56-7)
] |
|
Aprepitant
|
D000077608 |
[A morpholine neurokinin-1 (NK1) receptor antagonist that is used in the management of nausea and vomiting caused by DRUG THERAPY, and for the prevention of POSTOPERATIVE NAUSEA AND VOMITING.
] |
|
Aprindine
|
D001073 |
[A class Ib anti-arrhythmia agent used to manage ventricular and supraventricular arrhythmias.
] |
|
Aprotinin
|
D007611 |
[A single-chain polypeptide derived from bovine tissues consisting of 58 amino-acid residues. It is an inhibitor of proteolytic enzymes including CHYMOTRYPSIN; KALLIKREIN; PLASMIN; and TRYPSIN. It is used in the treatment of HEMORRHAGE associated with raised plasma concentrations of plasmin. It is also used to reduce blood loss and transfusion requirements in patients at high risk of major blood loss during and following open heart surgery with EXTRACORPOREAL CIRCULATION. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)
] |
