Highly conserved protein-serine threonine kinases that phosphorylate and activate a group of AGC protein kinases, especially in response to the production of the SECOND MESSENGERS, phosphatidylinositol 3,4,-biphosphate (PtdIns(3,4)P2) and phosphatidylinositol 3,4,5-triphosphate (PtdIns(3,4,5)P3).

Synonyms: Kinase-1, 3-Phosphoinositide-Dependent Protein, Kinases, 3-Phosphoinositide-Dependent Protein, 3-Phosphoinositide Dependent Protein Kinase-2, Kinase-2, 3-Phosphoinositide-Dependent Protein, 3-Phosphoinositide Dependent Protein Kinase-1, EC 2.7.11.1, Protein Kinase, 3-Phosphoinositide-Dependent, 3-Phosphoinositide-Dependent Protein Kinase-1, 3-Phosphoinositide-Dependent Protein Kinase-2, Kinase, 3-Phosphoinositide-Dependent Protein, 3 Phosphoinositide Dependent Protein Kinases, Protein Kinase-1, 3-Phosphoinositide-Dependent, 3 Phosphoinositide Dependent Protein Kinase, Protein Kinase-2, 3-Phosphoinositide-Dependent, PtdIns(3,4,5)P3-Dependent Protein Kinase-1, Protein Kinases, 3-Phosphoinositide-Dependent, 3 Phosphoinositide Dependent Protein Kinase 2, 3 Phosphoinositide Dependent Protein Kinase 1, 3-Phosphoinositide-Dependent Protein Kinase, 3-Phosphoinositide-Dependent Kinase 1 (PDK1), 3-Phosphoinositide-Dependent Protein Kinases