A group of PROTEIN-SERINE-THREONINE KINASES which activate critical signaling cascades in double strand breaks, APOPTOSIS, and GENOTOXIC STRESS such as ionizing ultraviolet A light, thereby acting as a DNA damage sensor. These proteins play a role in a wide range of signaling mechanisms in cell cycle control.

Synonyms: AT Mutated Protein, EC 2.7.11.1, Mutated Protein, AT, Protein, AT Mutated, Protein, A-T, A-T Protein, Ataxia Telangiectasia Mutated Proteins, A T Protein, ATM Protein