A degradation process whereby incorrectly folded proteins are selectively transported out of the ENDOPLASMIC RETICULUM and into the CYTOSOL. The misfolded proteins are subsequently ubiquitinated and degraded by the PROTEASOME.

Synonyms: Endoplasmic Reticulum-Associated Degradation, Reticulum-Associated Degradation, Endoplasmic, Degradation, Endoplasmic Reticulum-Associated, Pathway, ERAD, Endoplasmic Reticulum Associated Degradation, Pathways, ERAD, ERAD Pathway, ERAD Pathways