Any of various diseases affecting the white matter of the central nervous system.

Synonyms: CACH VWM Syndromes, Childhood Ataxia with Diffuse Central Nervous System Hypomyelination, Syndrome, CACH VWM, VWM Syndrome, CACH, Leukoencephalopathies, Vanishing White Matter Disease, Childhood Ataxia with Central Nervous System Hypomyelination, White Matter Diseases, Leukoencephalopathy, Childhood Ataxia with Central Nervous System Hypomyelinization, Diffusas, Myelinosis Centralis, Myelinosis Centralis Diffusa, Leukoencephalopathy with Vanishing White Matter, Vanishing White Matter Leukodystrophy, Cree Leukoencephalopathy, CACH VWM Syndrome, Diffusa, Myelinosis Centralis, CACH Syndrome, Myelinosis Centralis Diffusas, CACH Syndromes, Centralis Diffusa, Myelinosis, Cree Leukoencephalopathies, Leukoencephalopathy, Cree, White Matter Disease