A sub-class of protein tyrosine phosphatases that contain an additional phosphatase activity which cleaves phosphate ester bonds on SERINE or THREONINE residues that are located on the same protein.

Synonyms: Phosphatases, DUSP, Phosphatase, Dual-Specificity, Phosphatases, Dual-Specificity, Dual-Specificity Phosphatase, Dual-Specificity Phosphatases, EC 3.1.3.48, DUSP Phosphatases, Dual Specificity Phosphatases, Dual Specificity Phosphatase