A CARD signaling adaptor protein characterized by an N-terminal CARD DOMAIN and C-terminal WD40 REPEATS. It plays a role in the mitochondria-stimulated apoptosis (APOPTOSIS, INTRINSIC PATHWAY) and binds to CYTOCHROME C in the CYTOSOL to form an APOPTOSOMAL PROTEIN COMPLEX which activates INITIATOR CASPASES such as CASPASE 9.
Synonyms: 0, Apoptotic Protease-Activating Factor 1, Protease-Activating Factor, Apaf-1, Apoptotic Peptidase Activating Factor 1, Apaf 1 Protease Activating Factor, Apoptotic Protease Activating Factor 1, Apaf-1 Protease-Activating Factor
Instance information
2007(1997) ,2007; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1 was indexed under INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS 1997-2006 & under PROTEINS 1997-2005
D053477