A family of serine-threonine kinases that plays a role in intracellular signal transduction by interacting with a variety of signaling adaptor proteins such as CRADD SIGNALING ADAPTOR PROTEIN; TNF RECEPTOR-ASSOCIATED FACTOR 2; and TNF RECEPTOR-ASSOCIATED DEATH DOMAIN PROTEIN. Although they were initially described as death domain-binding adaptor proteins, members of this family may contain other protein-binding domains such as those involving caspase activation and recruitment.

Synonyms: RIP Serine-Threonine Kinase, RIP Serine-Threonine Kinases, Receptor Interacting Protein RIP, Receptor Interacting Protein Serine Threonine Kinase 3, Receptor-Interacting Protein Serine-Threonine Kinases, EC 2.7.11.1, Receptor Interacting Protein Serine Threonine Kinase 1, RIP Serine Threonine Kinases, RIP (Receptor Interacting Protein), RIP Serine Threonine Kinase, Serine-Threonine Kinases, RIP, Kinases, RIP Serine-Threonine, Kinase, RIP Serine-Threonine, Receptor Interacting Protein Serine Threonine Kinases, Receptor-Interacting Protein Serine-Threonine Kinase 1, Serine-Threonine Kinase, RIP, Receptor-Interacting Protein Serine-Threonine Kinase 3