A major and the second most common isoform of apolipoprotein E. In humans, Apo E4 differs from APOLIPOPROTEIN E3 at only one residue 112 (cysteine is replaced by arginine), and exhibits a lower resistance to denaturation and greater propensity to form folded intermediates. Apo E4 is a risk factor for ALZHEIMER DISEASE and CARDIOVASCULAR DISEASES.

Synonyms: 0, Apolipoprotein E-4, Apolipoprotein E4, Apolipoprotein E 4, Apo E-4, Apo E epsilon 4, Apo E 4, ApoE4, Apo E4