A costimulatory ligand glycoprotein that contains a C2 and V-type IMMUNOGLOBULIN DOMAIN. It is expressed by ANTIGEN-PRESENTING CELLS and binds to CD28 ANTIGEN with high specificity and to CTLA-4 ANTIGEN with low specificity. The interaction of CD86 with CD28 ANTIGEN provides a stimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.
Synonyms: Antigen, B7-2, Costimulatory Molecule, B70, Antigens, CD86, Costimulatory Molecule, B7-2, B7-2 Costimulatory Molecule, Early T Cell Costimulatory Molecule 1, B7 2 Antigen, CD86 Antigen, 0, B7-2 Antigen, Antigen, B7 2, B70 Costimulatory Molecule, CD86 Antigens, Antigen, CD86
Instance information
2018; see ANTIGENS, CD86 2006-2017; B7-2 ANTIGEN was indexed under MEMBRANE GLYCOPROTEINS and ANTIGENS, CD 1996-2005; and under B-CELL ACTIVATION ANTIGEN 1993-1995 ,2018 (1993)
D051940