A severe irreversible decline in the ability of kidneys to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism.

Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE.

Synonyms: Kidney Insufficiencies, Insufficiency, Kidney, Failure, Kidney, Renal Failures, Failures, Kidney, Kidney Failure, Kidney Failures, Failure, Renal, Renal Failure, Failures, Renal, Kidney Insufficiency, Renal Insufficiency, Renal Insufficiencies