An enzyme that catalyzes the oxidation of 1-pyrroline-5-carboxylate to L-GLUTAMATE in the presence of NAD. Defects in the enzyme are the cause of hyperprolinemia II.

Synonyms: Delta(1)-Pyrroline-5-Carboxylate Dehydrogenase, Dehydrogenase, 1-Pyrroline-5-Carboxylate, Glutamic Gamma Semialdehyde Dehydrogenase, Dehydrogenase, Glutamic-Gamma-Semialdehyde, EC 1.2.1.88, NADP+ Specific 8-Glutamate Semialdehyde Dehydrogenase, GGS Dehydrogenase, Glutamyl-Gamma-Semialdehyde Dehydrogenase, Dehydrogenase, Glutamyl-Gamma-Semialdehyde, 1-Pyrroline-5-Carboxylate Dehydrogenase, 1 Pyrroline 5 Carboxylate Dehydrogenase, Dehydrogenase, GGS, Glutamyl Gamma Semialdehyde Dehydrogenase, NADP+ Specific 8 Glutamate Semialdehyde Dehydrogenase, Glutamic-Gamma-Semialdehyde Dehydrogenase