A family of transcription factors that share an N-terminal HELIX-TURN-HELIX MOTIF and bind INTERFERON-inducible promoters to control GENE expression. IRF proteins bind specific DNA sequences such as interferon-stimulated response elements, interferon regulatory elements, and the interferon consensus sequence.

Synonyms: Interferon Regulatory Factor, 0, Interferon Regulatory Factors, Factor, Interferon Regulatory, Transcription Factors, IRF, Regulatory Factor, Interferon, IRF Transcription Factors