Dynamins that contain an alanine in position 44 instead of lysine. The amino acid substitution causes the protein to be GTPase-deficient and unable to function normally in the cell. GTPase-deficient dynamins are used experimentally to study dynamin function.
A family of high molecular weight GTP phosphohydrolases that play a direct role in vesicle transport. They associate with microtubule bundles (MICROTUBULES) and are believed to produce mechanical force via a process linked to GTP hydrolysis. This enzyme was formerly listed as EC 3.6.1.50.
Synonyms: 0, EC 3.6.5.5, Dynamin K44A, Dynamin, Mutated Form, K44A, GTPase-Deficient Dynamin, Dynamin, GTPase Deficient Dynamin, Dynamins, Dephosphin, Dynamin, Alanine44 Substituted With Lysine, Dynamin, GTPase-Deficient
Instance information
2003; use DYNAMINS (NM) 1989-2002 ,general or unspecified; prefer specifics ,2003; DYNAMIN (now DYNAMINS) was indexed under GTP PHOSPHOHYDROLASES 1 1994-2002 & CA(2+) MG(2+)-ATPASE 1989-1993
D034281