A large, nuclear protein, encoded by the BRCA2 gene (GENE, BRCA2). Mutations in this gene predispose humans to breast and ovarian cancer. The BRCA2 protein is an essential component of DNA repair pathways, suppressing the formation of gross chromosomal rearrangements. (from Genes Dev. 2000;14(11):1400-6)
Synonyms: Fanconi Anemia Group D1 Protein, Fanconi Anemia Complementation Group D1 Protein, 0, FANCD1 Protein, Fanconi Anemia Group D1 Complementing Protein, BRCA2 Gene Product, Breast Cancer 2 Gene Product, BRCA2 Protein, Breast Cancer 2 Protein
Instance information
comment
2002; use BRCA2 PROTEIN (NM) 1995-2001 ,2002; BCRA2 PROTEIN was indexed under NEOPLASM PROTEINS & TRANSCRIPTION FACTORS 1995-2001
identifier
D024682