A costimulatory ligand membrane glycoprotein that contains a V2 type and C2 IMMUNOGLOBULIN DOMAIN and is expressed by ANTIGEN-PRESENTING CELLS. It binds to CTLA-4 ANTIGEN with high specificity and to CD28 ANTIGEN with low specificity. The interaction of CD80 with CD28 ANTIGEN provides a costimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.
Synonyms: CD80 Antigen, B-Cell Activation Antigen, B7 1 Costimulatory Molecule, Costimulatory Molecule, B7-1, B Cell Activation Antigen, Antigen, B7-1, B7-1 Costimulatory Molecule, Antigens, CD80, B7 1 Antigen, 0, B7 1 Ligand, B7-1 Antigen, CD80 Antigens, Antigen, B7 1, Ligand, B7-1, B7-1 Ligand
Instance information
2018; see ANTIGENS, CD80 1996-2017; see B-CELL ACTIVATION ANTIGEN 1994-95; B7-1 ANTIGEN was indexed under B-CELL ACTIVATION ANTIGEN 1994-95; B CELL ACTIVATION ANTIGEN B7 was indexed under ANTIGENS, SURFACE 1991-93 ,2018 (1991)
D018122