An enzyme group that specifically dephosphorylates phosphotyrosyl residues in selected proteins. Together with PROTEIN-TYROSINE KINASE, it regulates tyrosine phosphorylation and dephosphorylation in cellular signal transduction and may play a role in cell growth control and carcinogenesis.

Synonyms: Tyrosine Phosphatases, Protein, Phosphatase, Phosphotyrosyl Protein, Phosphatase, Protein-Tyrosine, Phosphotyrosine Phosphatase, Phosphatase, Tyrosyl Phosphoprotein, Phosphoprotein Phosphatase, Tyrosyl, Phosphotyrosyl Protein Phosphatase, PTPase, Phosphatase, Phosphotyrosine, Protein-Tyrosine-Phosphatase, Protein Phosphatase, Phosphotyrosyl, Protein-tyrosine-phosphate phosphohydrolase, Protein Tyrosine Phosphatase, Protein-Tyrosine Phosphatase, Phosphatases, Protein Tyrosine, EC 3.1.3.48, Protein Tyrosine Phosphatases, Tyrosyl Phosphoprotein Phosphatase