An acidic glycoprotein of MW 23 kDa with internal disulfide bonds. The protein is produced in response to a number of inflammatory mediators by mesenchymal cells present in the hemopoietic environment and at peripheral sites of inflammation. GM-CSF is able to stimulate the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells and can stimulate the formation of eosinophil colonies from fetal liver progenitor cells. GM-CSF can also stimulate some functional activities in mature granulocytes and macrophages.

Synonyms: Histamine Producing Cell Stimulating Factor, Cell-Stimulating Factor, Histamine-Producing, Histamine-Producing Cell-Stimulating Factor, Tumor-Cell Human GM Colony-Stimulating Factor, CSF-2, 83869-56-1, Colony-Stimulating Factor, Granulocyte-Macrophage, Colony-stimulating factor 2, GM-CSF, Granulocyte Macrophage Colony Stimulating Factor, Colony Stimulating Factor, Granulocyte Macrophage, TC-GM-CSF, CSF-GM, Granulocyte-Macrophage Colony-Stimulating Factor, Tumor Cell Human GM Colony Stimulating Factor