Procedures by which protein structure and function are changed or created in vitro by altering existing or synthesizing new structural genes that direct the synthesis of proteins with sought-after properties. Such procedures may include the design of MOLECULAR MODELS of proteins using COMPUTER GRAPHICS or other molecular modeling techniques; site-specific mutagenesis (MUTAGENESIS, SITE-SPECIFIC) of existing genes; and DIRECTED MOLECULAR EVOLUTION techniques to create new genes.

Synonyms: Engineering, Protein, Genetic Engineering, Protein, Protein Engineering, Engineering, Protein Genetic, Genetic Engineering of Proteins, Protein Genetic Engineering, Proteins, Genetic Engineering