Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.

Synonyms: 0, Cachectin, TNF-alpha, Tumor Necrosis Factor Ligand Superfamily Member 2, Cachectin Tumor Necrosis Factor, TNFalpha, Cachectin-Tumor Necrosis Factor, TNF Superfamily, Member 2, Tumor Necrosis Factor-alpha, Tumor Necrosis Factor, Tumor Necrosis Factor alpha