A mitochondrial cytochrome P450 enzyme that catalyzes the 11-beta-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11B1 gene, is important in the synthesis of CORTICOSTERONE and HYDROCORTISONE. Defects in CYP11B1 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL).

Synonyms: CYP 11B1, Steroid-11-Hydroxylase, Cytochrome P-450 CYP11B1, Cytochrome P-450(11 beta), Steroid 11-beta-Hydroxylase, Cytochrome P450 11B1, Steroid 11 Hydroxylase, Steroid 11-beta-Monooxygenase, Cytochrome P 450 CYP11B1, 11 beta Hydroxylase, EC 1.14.15.4, 11 beta-Hydroxylase, CYP11B1, Steroid 11-Hydroxylase, Steroid 11 beta Monooxygenase, Steroid 11 beta Hydroxylase, Steroid, reduced-adrenal-ferredoxin:oxygen oxidoreductase (11 beta-hydroxylating)