A DNA-dependent RNA polymerase present in bacterial, plant, and animal cells. It functions in the nucleoplasmic structure where it transcribes DNA into RNA. It has specific requirements for cations and salt and has shown an intermediate sensitivity to alpha-amanitin in comparison to RNA polymerase I and II.

Synonyms: RNA Polymerase C, RNA Polymerase III, EC 2.7.7.6, Polymerase C, RNA, DNA-Dependent RNA Polymerase III, DNA Dependent RNA Polymerase III, Polymerase III, RNA