Enzyme complexes that catalyze the formation of PROSTAGLANDINS from the appropriate unsaturated FATTY ACIDS, molecular OXYGEN, and a reduced acceptor.

Synonyms: Fatty Acid Cyclo-Oxygenase, G-H Synthase, Prostaglandin, Prostaglandin H2 Synthetase, Prostaglandin H Synthase, Prostaglandin-Endoperoxide Synthase, Prostaglandin Synthase, Cyclo-Oxygenase, Prostaglandin Cyclo-Oxygenase, Hydroperoxide Cyclase, Synthase, Prostaglandin-Endoperoxide, Cyclooxygenases, Endoperoxide Synthetase, Prostaglandin, Prostaglandin G-H Synthase, Cyclooxygenase, Prostaglandin Synthetase, Prostaglandin Endoperoxide Synthases, Cyclooxygenase, Arachidonic Acid, Prostaglandin-Endoperoxide Synthases, PGH2 Synthetase, Synthase, Prostaglandin G-H, Synthase, PGH, Cyclo Oxygenase, Synthase, Prostaglandin, Synthetase, PGH2, Fatty Acid Cyclo Oxygenase, Prostaglandin G H Synthase, PGH Synthase, Prostaglandin Cyclo Oxygenase, EC 1.14.99.1, Cyclo-Oxygenase, Prostaglandin, Prostaglandin Endoperoxide Synthetase, Synthases, Prostaglandin-Endoperoxide, Cyclooxygenase, Prostaglandin, Prostaglandin Cyclooxygenase, Synthetase, Prostaglandin H2, Synthetase, Prostaglandin Endoperoxide, Synthetase, Prostaglandin, Arachidonic Acid Cyclooxygenase, Cyclo-Oxygenase, Fatty Acid, Synthase, Prostaglandin H, Cyclase, Hydroperoxide, (5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase