A 30-kDa protein synthesized primarily in the ANTERIOR PITUITARY GLAND and the HYPOTHALAMUS. It is also found in the skin and other peripheral tissues. Depending on species and tissues, POMC is cleaved by PROHORMONE CONVERTASES yielding various active peptides including ACTH; BETA-LIPOTROPIN; ENDORPHINS; MELANOCYTE-STIMULATING HORMONES; and others (GAMMA-LPH; CORTICOTROPIN-LIKE INTERMEDIATE LOBE PEPTIDE; N-terminal peptide of POMC or NPP).

Synonyms: Pre-POMC, Pre pro opiocortin, 78321-08-1, Proopiomelanocortin, Corticotropin beta Lipotropin Precursor, ACTH-beta-Lipotropin Precursor, Corticotropin-beta-Lipotropin Precursor, 66796-54-1, Proopiocortin, Pro-Opiocortin, Opiomelanocortin, pro-, Pro-Opio-Melanocortin, Pre-pro-opiocortin, Pro Opiomelanocortin, Pro Opio Melanocortin, Endorphin-ACTH Precursor, Pro ACTH Endorphin, POMC, Opiocortin, Pre POMC, 76775-14-9, Pro-ACTH-Endorphin, ACTH-Endorphin Precursor, ACTH Endorphin Precursor, ACTH beta Lipotropin Precursor, Pro Opiocortin, Endorphin ACTH Precursor, Preproopiomelanocortin, Pro-Opiomelanocortin