The condition of a pattern of malignancies within a family, but not every individual's necessarily having the same neoplasm. Characteristically the tumor tends to occur at an earlier than average age, individuals may have more than one primary tumor, the tumors may be multicentric, usually more than 25 percent of the individuals in direct lineal descent from the proband are affected, and the cancer predisposition in these families behaves as an autosomal dominant trait with about 60 percent penetrance.

Synonyms: Cancer Syndromes, Hereditary, Cancer Syndrome, Hereditary, Hereditary Neoplastic Syndromes, Syndromes, Hereditary Cancer, Syndrome, Hereditary Cancer, Hereditary Neoplastic Syndrome, Hereditary Cancer Syndrome, Syndrome, Hereditary Neoplastic, Syndromes, Hereditary Neoplastic, Hereditary Cancer Syndromes, Neoplastic Syndrome, Hereditary, Neoplastic Syndromes, Hereditary