An enzyme secreted from the liver into the plasma of many mammalian species. It catalyzes the esterification of the hydroxyl group of lipoprotein cholesterol by the transfer of a fatty acid from the C-2 position of lecithin. In familial lecithin:cholesterol acyltransferase deficiency disease, the absence of the enzyme results in an excess of unesterified cholesterol in plasma.

Synonyms: O-Acyltransferase, Phosphatidylcholine-Sterol, Lecithin Cholesterol Acyltransferase, Phosphatidylcholine-Sterol O-Acyltransferase, Cholesterol Acyltransferase, Lecithin, Acyltransferase, Lecithin, Cholesterol Ester Lysolecithin Acyltransferase, Phosophatidylcholine Sterol Acyltransferase, Phosphatidylcholine:sterol O-acyltransferase, Acyltransferase, Lecithin Cholesterol, Phosphatidylcholine Sterol O Acyltransferase, Acyltransferase, Phosophatidylcholine-Sterol, Phosophatidylcholine-Sterol Acyltransferase, Lecithin Acyltransferase, EC 2.3.1.43