A sex-specific cell surface antigen produced by the sex-determining gene of the Y chromosome in mammals. It causes syngeneic grafts from males to females to be rejected and interacts with somatic elements of the embryologic undifferentiated gonad to produce testicular organogenesis.

Synonyms: 0, H Y Antigen, Antigen, H-Y, GA 1 Germ Cell Antigen, Antigen, HY, GA-1 Germ Cell Antigen, HY Antigen, H-Y Antigen