A hereditary motor and sensory neuropathy transmitted most often as an autosomal dominant trait and characterized by progressive distal wasting and loss of reflexes in the muscles of the legs (and occasionally involving the arms). Onset is usually in the second to fourth decade of life. This condition has been divided into two subtypes, hereditary motor and sensory neuropathy (HMSN) types I and II. HMSN I is associated with abnormal nerve conduction velocities and nerve hypertrophy, features not seen in HMSN II. (Adams et al., Principles of Neurology, 6th ed, p1343)

Synonyms: Charcot Marie Tooth Disease, Type 1B, Charcot Marie Tooth Disease, Type 1A, Charcot-Marie-Tooth Disease, Autosomal Dominant, with Focally Folded Myelin Sheaths, Type 1B, Charcot-Marie Disease, HMSN I, Areflexic Dystasias, Hereditary, Charcot-Marie-Tooth Disease, HMSN1A, HMSN1B, Peroneal Muscular Atrophies, Charcot Marie Tooth Disease, Type II, Hereditary Motor And Sensory Neuropathy IB, Atrophy, Peroneal Muscular, Charcot-Marie-Tooth Disease, Autosomal Dominant, With Focally Folded Myelin Sheaths, Type 1A, Charcot Marie Tooth Disease, Type I, Atrophies, Peroneal Muscular, Charcot Marie Tooth Neuropathy, Type 1B, Dystasias, Hereditary Areflexic, Charcot Marie Tooth Neuropathy, Type 1A, Hereditary Areflexic Dystasia, Hereditary Areflexic Dystasias, Roussy-Levy Hereditary Areflexic Dystasia, Hereditary Neuropathy, Charcot-Marie-Tooth, Charcot Marie Tooth Disease, Type IB, Charcot Marie Tooth Disease, Type IA, Hereditary Motor, and Sensory Neuropathy Type I, Charcot-Marie-Tooth Neuropathy, Type 1B, HMSN Type I, Charcot-Marie-Tooth Disease, Type II, Charcot-Marie-Tooth Neuropathy, Type 1A, Peroneal Muscular Atrophy, Syndrome, Roussy-Levy, Charcot-Marie-Tooth Disease, Slow Nerve Conduction Type, Linked To Duffy, Charcot-Marie-Tooth Disease, Type IA, Roussy-Levy Syndrome, Charcot-Marie-Tooth Disease, Type IB, HMSN IB, Charcot-Marie-Tooth Syndrome, HMSN IA, Charcot-Marie-Tooth Disease, Type 1A, Hereditary Motor and Sensory-Neuropathy Type II, Charcot-Marie-Tooth Disease, Type 1B, Areflexic Dystasia, Hereditary, Roussy Levy Syndrome, Charcot-Marie-Tooth Disease, Demyelinating, Type 1B, Charcot-Marie-Tooth Disease, Demyelinating, Type 1A, HMN Distal Type I, HMSN Type II, Charcot Marie Tooth Hereditary Neuropathy, Muscular Atrophy, Peroneal, Hereditary Type I Motor and Sensory Neuropathy, Charcot Marie Tooth Syndrome, Roussy-Levy Disease, Charcot Marie Disease, Hereditary Motor and Sensory Neuropathy 1B, Neuropathy, Type II Hereditary Motor and Sensory, Roussy Levy Disease, Hereditary Motor and Sensory Neuropathy 1A, Hereditary Motor and Sensory Neuropathy IA, Neuropathy, Type I Hereditary Motor and Sensory, Syndrome, Charcot-Marie-Tooth, HMSN 1B, HMSN 1A, Charcot Marie Tooth Disease, Charcot-Marie-Tooth Disease, Type I, Charcot-Marie-Tooth Hereditary Neuropathy, Muscular Atrophies, Peroneal, Roussy Levy Hereditary Areflexic Dystasia, Atrophy, Muscular, Peroneal, HMSN II, Dystasia, Hereditary Areflexic, Hereditary Motor and Sensory Neuropathy Type II