A group of disorders caused by defective salt reabsorption in the ascending LOOP OF HENLE. It is characterized by severe salt-wasting, HYPOKALEMIA; HYPERCALCIURIA; metabolic ALKALOSIS, and hyper-reninemic HYPERALDOSTERONISM without HYPERTENSION. There are several subtypes including ones due to mutations in the renal specific SODIUM-POTASSIUM-CHLORIDE SYMPORTERS.

Synonyms: Syndrome, Bartter's, Juxtaglomerular Hyperplasia with Secondary Aldosteronism, Bartters Syndrome, Syndrome, Bartter, Bartters Disease, Aldosteronism with Hyperplasia of the Adrenal Cortex, Bartter's Disease, Bartter Disease, Bartter's Syndrome, Bartter Syndrome