An enzyme that catalyzes the oxidation of arachidonic acid to yield 12-hydroperoxyarachidonate (12-HPETE) which is itself rapidly converted by a peroxidase to 12-hydroxy-5,8,10,14-eicosatetraenoate (12-HETE). The 12-hydroperoxides are preferentially formed in PLATELETS.

Synonyms: Arachidonate:oxygen 12-oxidoreductase, EC 1.13.11.31, 12 Lipoxygenase, Arachidonic Acid 12-Lipoxygenase, 12-Lipoxygenase, Arachidonate, Arachidonic Acid 12 Lipoxygenase, 12-Lipoxygenase, Arachidonate 12-Lipoxygenase, Arachidonate 12 Lipoxygenase, 12-Lipoxygenase, Arachidonic Acid