The phenomenon of antibody-mediated target cell destruction by non-sensitized effector cells. The identity of the target cell varies, but it must possess surface IMMUNOGLOBULIN G whose Fc portion is intact. The effector cell is a "killer" cell possessing Fc receptors. It may be a lymphocyte lacking conventional B- or T-cell markers, or a monocyte, macrophage, or polynuclear leukocyte, depending on the identity of the target cell. The reaction is complement-independent.

Synonyms: Cell Cytoxicity, Antibody Dependent, Cytotoxicities, Antibody-Dependent Cell, Cytotoxicity, Antibody Dependent Cell, Antibody-Dependent Cell Cytotoxicity, Cell Cytotoxicities, Antibody-Dependent, Cell Cytoxicity, Antibody-Dependent, Cell Cytoxicities, Antibody-Dependent, Cytoxicities, Antibody-Dependent Cell, Antibody Dependent Cell Cytotoxicity, Antibody-Dependent Cell Cytotoxicities, Cytotoxicity, Antibody-Dependent Cell, Cell Cytotoxicity, Antibody-Dependent, Antibody-Dependent Cell Cytoxicities, Antibody-Dependent Cell Cytoxicity, Cytoxicity, Antibody-Dependent Cell, ADCC