A transmembrane glycoprotein with an extracellular catalytic domain which functions as a carboxypeptidase. It cleaves a single C-terminal residue from a distinct range of substrates. The catalytic efficiency is 400-fold higher with ANGIOTENSIN II as a substrate than with ANGIOTENSIN I. Angiotensin-converting enzyme 2 is also is a functional receptor for the spike glycoprotein (SPIKE PROTEIN, CORONAVIRUS) of the CORONAVIRUSES SARS-COV, SARS-COV2, and HCOV-NL63.

Synonyms: EC 3.4.17.23, ACE2 Protein, ACE2 Angiotensin-Converting Enzyme Protein 2, Angiotensin Converting Enzyme Related Carboxypeptidase, Carboxypeptidase, Angiotensin-Converting Enzyme-Related, Angiotensin-Converting Enzyme-Related Carboxypeptidase, Angiotensin-Converting Enzyme 2, ACE2 Enzyme, ACE-Related Carboxypeptidase, Angiotensin Converting Enzyme 2, ACE2 Angiotensin Converting Enzyme Protein 2, ACE Related Carboxypeptidase, Carboxypeptidase, ACE-Related