Mitochondrial Permeability Transition Pore
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A multiprotein inner mitochondrial complex which opens only under certain pathological conditions (e.g., OXIDATIVE STRESS) uncoupling the membrane leading to APOPTOSIS and MITOCHONDRIAL TRANSMEMBRANE PERMEABILITY-DRIVEN NECROSIS particularly in CARDIOMYOCYTES during MYOCARDIAL REPERFUSION INJURY.
Synonyms: 0, Mitochondrial Permeability Transition Pore (mPTP), Mitochondrial Permeability Transition Pore, mPTP Protein, Mitochondrial Megachannel
Instance information
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2021(1999) ,Mitochondrial Permeability Transition Pore was indexed under MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS 2007-2020; ION CHANNELS 2003-2006; MEMBRANE PROTEINS 1999-2002; CYCLOSPORINS 1999-2000
identifier
D000083162