A nonproliferative disorder of the PLASMA CELL characterized by excessive production and misfolding of IMMUNOGLOBULIN LIGHT CHAINS that form insoluble amyloid fibrils (see AMYLOID DEPOSITS) in various tissues. Clinical features include LIVER FAILURE; MULTIPLE MYELOMA; NEPHROTIC SYNDROME; RESTRICTIVE CARDIOMYOPATHY, and neuropathies.

Synonyms: Immunoglobulin Light chain Amyloidosis, Amyloidoses, Primary, Amyloidoses, Primary Systemic, AL Amyloidoses, Amyloidosis, Immunoglobulin Light-chain, Systemic Amyloidosis, Primary, AL Amyloidosis, Amyloidosis, Primary Systemic, Primary Amyloidosis, Amyloidosis, Primary, Immunoglobulin Light-chain Amyloidoses, Primary Systemic Amyloidoses, Primary Amyloidoses, Amyloidosis, Immunoglobulin Light chain, Primary Systemic Amyloidosis, Systemic Amyloidoses, Primary, Immunoglobulin Light-chain Amyloidosis