A UBIQUITIN-like modifier protein that functions in AUTOPHAGOSOME formation, CYTOPLASM to VACUOLE transport, MITOPHAGY, and nucleophagy. Conjugation with ATG5 PROTEIN or ATG10 is essential for its function. The ATG12-ATG5 conjugate acts as an E3 UBIQUITIN LIGASE-like enzyme for lipid modification of ATG8 FAMILY PROTEINS and their localization to vesicle membranes.

Synonyms: Autophagy-Related Protein 12, 0, ATG12 Protein, Ubiquitin Like Protein ATG12, ATG12, Ubiquitin-Like Protein, Autophagy Related Protein 12, Ubiquitin-Like Protein ATG12