An autophagy related protein which functions as a core subunit of PHOSPHATIDYLINOSITOL 3-KINASE MULTIPROTEIN COMPLEXES. It mediates the formation of phosphatidylinositol 3-phosphate and functions in AUTOPHAGY, where it is required for maturation of the AUTOPHAGOSOME. It also functions in ENDOCYTOSIS and CYTOKINESIS as part of a separate complex. Beclin-1 associates with INTRACELLULAR MEMBRANES and interacts with the PROTO-ONCOGENE PROTEINS C-BCL-2 and BCL-X PROTEIN.

Synonyms: ATG 6 Protein, Beclin-1, 0, Coiled coil Myosin like Bcl2 interacting Protein, ATG6 Protein, Beclin 1 Protein, Beclin-1 Protein, Beclin 1, ATG-6 Protein, Beclin1, GT197 Protein, Coiled-coil Myosin-like Bcl2-interacting Protein